The genetic integrity of the sperm is essential for the success of fertilization and normal embryo development. Sperm DNA fragmentation refers to the abnormality of the sperm genome, which may lead to male infertility.
Studies show that high sperm fragmentation does not affect fertilization or embryo cleavage stages but affect the subsequent blastocyst development. It also significantly compromises the possibility of successful pregnancy in assisted conception treatment. Higher the DNA fragmentation, higher the chance of miscarriages. High sperm DNA fragmentation is also found in men with poor and normal semen parameters.
DNA fragmentation cannot be detected in the semen analysis, but there are many sperm DNA fragmentation tests available to assess the sperm at the molecular level.
Change in the lifestyle and treatment may help to reduce the levels of DNA fragmentation.
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